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Microbiology Mechanism Online Action: Tinidazole is an antiprotozoal, antibacterial agent. The nitro- group of tinidazole is reduced by cell extracts of Trichomonas. Posts navigation The free nitro- radical generated as a result of this reduction may be responsible for the antiprotozoal activity.

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Tinidazole was negative for mutagenicity in a mammalian cell culture system utilizing Chinese hamster lung V79 cells HGPRT test system and negative for genotoxicity in the Chinese hamster ovary CHO sister chromatid exchange assay. Tinidazole was positive for in vivo genotoxicity in the mouse micronucleus assay.

This effect is characteristic of agents in the 5-nitroimidazole class.


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